Immunoprecipitation of SMAD6 transfected lysate using anti-SMAD6 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with SMAD6 purified MaxPab mouse polyclonal antibody (B01P) (H00004091-B01P).
The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants encoding different isoforms have been found for this gene
MAD (mothers against decapentaplegic, Drosophila) homolog 6,MAD, mothers against decapentaplegic homolog 6,Mothers against decapentaplegic, drosophila, homolog of, 6,SMAD, mothers against DPP homolog 6