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LRP6 Pre-design Chimera RNAi

  • Catalog # : H00004040-R02
  • Visit Frequency :
  • Countries :
  • Specification
  • Product Description:
  • Homo sapiens low density lipoprotein receptor-related protein 6 (LRP6), mRNA.
  • Reactivity:
  • Human
  • Supplied Product:
  • DEPC water
  • Target Refseq:
  • NM_002336
  • Storage Instruction:
  • Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
  • Note:
  • Position of the Chimera RNAi.

  • Publication Reference
  • Applications
  • RNAi Knockdown
  • Application Image
  • RNAi Knockdown
  • Gene Information
  • Entrez GeneID:
  • 4040
  • Gene Name:
  • LRP6
  • Gene Alias:
  • ADCAD2,FLJ90062,FLJ90421
  • Gene Description:
  • low density lipoprotein receptor-related protein 6
  • Gene Summary:
  • The LRP6 gene encodes a member of the low density lipoprotein receptor (LDLR) gene family, which consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDLR proteins are comprised of the same basic structural motifs: an extracellular domain that contains LDLR binding repeats and EGF repeats with associated spacer domains containing the YWTD motif; a single transmembrane-spanning domain; and a C-terminal cytoplasmic domain that generally contains at least 1 copy of the NPXY motif (Brown et al., 1998 [PubMed 9704021]). LRP6 and LRP5 (MIM 603506) function as coreceptors for WNT (MIM 164820) ligands and thus play a role in WNT signaling, which is important in a wide variety of biologic processes during pre- and postnatal life in invertebrates and vertebrates (Kokubu et al., 2004 [PubMed 15469977]).[supplied by OMIM
  • Other Designations:
  • low density lipoprotein-related protein 6
  • Gene Pathway
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