LIMK2 purified MaxPab rabbit polyclonal antibody (D01P)
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More Files
- More Functions
Western Blot (Tissue lysate)
LIMK2 MaxPab rabbit polyclonal antibody. Western Blot analysis of LIMK2 expression in human liver.
Western Blot (Tissue lysate)
LIMK2 MaxPab rabbit polyclonal antibody. Western Blot analysis of LIMK2 expression in mouse kidney.
Western Blot (Transfected lysate)
Western Blot analysis of LIMK2 expression in transfected 293T cell line (H00003985-T01) by LIMK2 MaxPab polyclonal antibody.
Lane 1: LIMK2 transfected lysate(77.90 KDa).
Lane 2: Non-transfected lysate.
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human LIMK2 protein.
Immunogen
LIMK2 (NP_001026971.1, 1 a.a. ~ 686 a.a) full-length human protein.
Sequence
MGSYLSVPAYFTSRDLFRCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRAPPGAAGEGPGCADDEGPVRRQGKVTIKYDPKELRKHLNLEEWILEQLTRLYDCQEEEISELEIDVDELLDMESDDAWASRVKELLVDCYKPTEAFISGLLDKIRAMQKLSTPQKK
Host
Rabbit
Reactivity
Human, Mouse
Interspecies Antigen Sequence
Mouse (95); Rat (95)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
LIMK2 MaxPab rabbit polyclonal antibody. Western Blot analysis of LIMK2 expression in human liver.Western Blot (Tissue lysate)
LIMK2 MaxPab rabbit polyclonal antibody. Western Blot analysis of LIMK2 expression in mouse kidney.Western Blot (Transfected lysate)
Western Blot analysis of LIMK2 expression in transfected 293T cell line (H00003985-T01) by LIMK2 MaxPab polyclonal antibody.
Lane 1: LIMK2 transfected lysate(77.90 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — LIMK2
Entrez GeneID
3985GeneBank Accession#
NM_001031801.1Protein Accession#
NP_001026971.1Gene Name
LIMK2
Gene Alias
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Gene Description
LIM domain kinase 2
Omim ID
601988Gene Ontology
HyperlinkGene Summary
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
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Interactome
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