LIMK1 monoclonal antibody (M05), clone 2E9
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant LIMK1.
Immunogen
LIMK1 (NP_002305, 548 a.a. ~ 647 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
ADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRRGESGLPAHPEVPD
Host
Mouse
Reactivity
Human
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.74 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
LIMK1 monoclonal antibody (M05), clone 2E9 Western Blot analysis of LIMK1 expression in HeLa ( Cat # L013V1 ).Western Blot (Recombinant protein)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of monoclonal antibody to LIMK1 on formalin-fixed paraffin-embedded human cerebellum. [antibody concentration 3 ug/ml]Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged LIMK1 is approximately 0.3ng/ml as a capture antibody.ELISA
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Gene Info — LIMK1
Entrez GeneID
3984GeneBank Accession#
NM_002314Protein Accession#
NP_002305Gene Name
LIMK1
Gene Alias
LIMK
Gene Description
LIM domain kinase 1
Omim ID
601329Gene Ontology
HyperlinkGene Summary
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is likely to be a component of an intracellular signaling pathway and may be involved in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. [provided by RefSeq
Other Designations
LIM motif-containing protein kinase|OTTHUMP00000025066
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Interactome
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Pathway
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Disease
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Publication Reference
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RAC1 Involves in the Radioresistance by Mediating Epithelial-Mesenchymal Transition in Lung Cancer.
Shiming Tan, Pin Yi, Heran Wang, Longzheng Xia, Yaqian Han, Hui Wang, Biao Zeng, Lu Tang, Qing Pan, Yutong Tian, Shan Rao, Linda Oyang, Jiaxin Liang, Jinguan Lin, Min Su, Yingrui Shi, Qianjin Liao, Yujuan Zhou.
Frontiers in Oncology 2020 Apr; 10:649.
Application:WB, Human, A549, PC9 cells.
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RAC1 Involves in the Radioresistance by Mediating Epithelial-Mesenchymal Transition in Lung Cancer.
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