LIG1 monoclonal antibody (M01), clone AG12
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant LIG1.
Immunogen
LIG1 (NP_000225, 810 a.a. ~ 919 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
QSLKALVLPSPRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQSQIQNQQGEDSGSDPEDTY
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (84%)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.84 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
LIG1 monoclonal antibody (M01), clone AG12 Western Blot analysis of LIG1 expression in Hela S3 NE ( Cat # L013V3 ).Western Blot (Recombinant protein)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of monoclonal antibody to LIG1 on formalin-fixed paraffin-embedded human stomach. [antibody concentration 1.2 ug/ml]Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged LIG1 is approximately 0.3ng/ml as a capture antibody.ELISA
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Gene Info — LIG1
Entrez GeneID
3978GeneBank Accession#
NM_000234Protein Accession#
NP_000225Gene Name
LIG1
Gene Alias
MGC117397, MGC130025
Gene Description
ligase I, DNA, ATP-dependent
Omim ID
126391Gene Ontology
HyperlinkGene Summary
LIG1 encodes DNA ligase I, with functions in DNA replication and the base excision repair process. Mutations in LIG1 that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. [provided by RefSeq
Other Designations
DNA ligase I
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Interactome
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Pathway
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Disease
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Publication Reference
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Reduced expression of DNA repair genes and chemosensitivity in 1p19q codeleted lower-grade gliomas.
Tang L, Deng L, Bai HX, Sun J, Neale N, Wu J, Wang Y, Chang K, Huang RY, Zhang PJ, Li X, Xiao B, Cao Y, Tao Y, Yang L.
Journal of Neuro-oncology 2018 Jun; [Epub].
Application:WB-Tr, Human, HS683 cells.
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Reduced expression of DNA repair genes and chemosensitivity in 1p19q codeleted lower-grade gliomas.
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