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LDLR 293T Cell Transient Overexpression Lysate(Denatured)

  • Catalog # : H00003949-T01
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  • Specification
  • Transfected Cell Line:
  • 293T
  • Plasmid:
  • pCMV-LDLR full-length
  • Host:
  • Human
  • Theoretical MW (kDa):
  • 94.6
  • Quality Control Testing:
  • Transient overexpression cell lysate was tested with Anti-LDLR antibody (H00003949-B01) by Western Blots.
    SDS-PAGE Gel
    QC Testing of H00003949-T01
    LDLR transfected lysate
    Western Blot
    QC Testing of H00003949-T01
    Lane 1: LDLR transfected lysate ( 94.6 KDa).
    Lane 2: Non-transfected lysate.
  • Storage Buffer:
  • 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot
  • Application Image
  • Western Blot
  • Gene Information
  • Entrez GeneID:
  • 3949
  • Gene Name:
  • LDLR
  • Gene Alias:
  • FH,FHC
  • Gene Description:
  • low density lipoprotein receptor
  • Gene Summary:
  • The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. [provided by RefSeq
  • Other Designations:
  • LDL receptor,low-density lipoprotein receptor class A domain-containing protein 3
  • Gene Pathway
  • Related Disease
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