L1CAM (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human L1CAM partial ORF ( NP_000416, 23 a.a. - 132 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
PEEYEGHHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMA
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
37.84
Interspecies Antigen Sequence
Mouse (83)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — L1CAM
Entrez GeneID
3897GeneBank Accession#
NM_000425Protein Accession#
NP_000416Gene Name
L1CAM
Gene Alias
CAML1, CD171, HSAS, HSAS1, MASA, MIC5, N-CAML1, S10, SPG1
Gene Description
L1 cell adhesion molecule
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant. [provided by RefSeq
Other Designations
OTTHUMP00000025992|antigen identified by monoclonal antibody R1|neural cell adhesion molecule L1
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Interactome
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Pathway
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Disease
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