KNS2 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-KNS2 full-length
Host
Human
Theoretical MW (kDa)
63.8
Interspecies Antigen Sequence
Mouse (98); Rat (98)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-KNS2 antibody (H00003831-B01) by Western Blots.
SDS-PAGE Gel
KLC1 transfected lysate.
Western Blot
Lane 1: KLC1 transfected lysate ( 63.8 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — KLC1
Entrez GeneID
3831GeneBank Accession#
NM_005552Protein Accession#
NP_005543.2Gene Name
KLC1
Gene Alias
KLC, KNS2, KNS2A, MGC15245
Gene Description
kinesin light chain 1
Omim ID
600025Gene Ontology
HyperlinkGene Summary
Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq
Other Designations
kinesin 2 (60-70kD)|kinesin 2 60/70kDa|medulloblastoma antigen MU-MB-2.50
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Interactome
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Disease
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