KISS1 monoclonal antibody (M03), clone 1D11
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant KISS1.
Immunogen
KISS1 (NP_002247, 46 a.a. ~ 145 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
PGEQSLPCTERKPAATARLSRRGTSLSPPPESSGSPQQPGLSAPHSRQIPAPQGAVLVQREKDLPNYNWNSFGLRFGKREAAPGNHGRSAGRGWGAGAGQ
Host
Mouse
Reactivity
Human
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.74 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of KISS1 expression in transfected 293T cell line by KISS1 monoclonal antibody (M03), clone 1D11.
Lane 1: KISS1 transfected lysate(14.7 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged KISS1 is approximately 0.03ng/ml as a capture antibody.ELISA
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Gene Info — KISS1
Entrez GeneID
3814GeneBank Accession#
NM_002256Protein Accession#
NP_002247Gene Name
KISS1
Gene Alias
KiSS-1, METASTIN, MGC39258
Gene Description
KiSS-1 metastasis-suppressor
Omim ID
603286Gene Ontology
HyperlinkGene Summary
This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may function to inhibit chemotaxis and invasion, attenuating metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues. [provided by RefSeq
Other Designations
OTTHUMP00000034312|kisspeptin|malignant melanoma metastasis-suppressor
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Interactome
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Disease
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