KIR2DL3 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-KIR2DL3 full-length
Host
Human
Theoretical MW (kDa)
37.9
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-KIR2DL3 antibody (H00003804-D01P) by Western Blots.
SDS-PAGE Gel
KIR2DL3 transfected lysate.
Western Blot
Lane 1: KIR2DL3 transfected lysate ( 37.90 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — KIR2DL3
Entrez GeneID
3804GeneBank Accession#
NM_015868.2Protein Accession#
NP_056952.2Gene Name
KIR2DL3
Gene Alias
CD158B2, CD158b, GL183, KIR-023GB, KIR-K7b, KIR-K7c, KIRCL23, MGC129943, NKAT, NKAT2, NKAT2A, NKAT2B, p58
Gene Description
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
Omim ID
604938Gene Ontology
HyperlinkGene Summary
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq
Other Designations
NK-receptor|killer cell immunoglobulin-like receptor 2DL3|natural killer associated transcript 2|natural killer cell inhibitory receptor KIR2DL3|p58 natural killer cell receptor|p58.2 MHC class-I specific NK receptor
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