KIR2DL1 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-KIR2DL1 full-length
Host
Human
Theoretical MW (kDa)
41.4
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-KIR2DL1 antibody (H00003802-B01) by Western Blots.
SDS-PAGE Gel
KIR2DL1 transfected lysate.
Western Blot
Lane 1: KIR2DL1 transfected lysate ( 41.4 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — KIR2DL1
Entrez GeneID
3802GeneBank Accession#
BC069344.1Protein Accession#
-Gene Name
KIR2DL1
Gene Alias
CD158A, KIR-K64, KIR221, NKAT, NKAT1, p58.1
Gene Description
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
Omim ID
604936Gene Ontology
HyperlinkGene Summary
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq
Other Designations
killer inhibitory receptor 2-2-1|natural killer-associated transcript 1|p58 NK cell inhibitory receptor NKR-K6|p58 killer cell inhibitory receptor KIR-K64|p58 natural killer cell receptor
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Interactome
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Disease
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