Western blot analysis of KHK over-expressed 293 cell line, cotransfected with KHK Validated Chimera RNAi ( Cat # H00003795-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with KHK monoclonal antibody (M01), clone 1H6-2B6 (Cat # H00003795-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq