KCNQ3 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human KCNQ3 peptide using ARM Technology.
Immunogen
A synthetic peptide of human KCNQ3 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human KCNQ3 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — KCNQ3
Entrez GeneID
3786GeneBank Accession#
KCNQ3Gene Name
KCNQ3
Gene Alias
BFNC2, EBN2, KV7.3
Gene Description
potassium voltage-gated channel, KQT-like subfamily, member 3
Gene Ontology
HyperlinkGene Summary
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and one of two related proteins encoded by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2). [provided by RefSeq
Other Designations
potassium channel, voltage-gated, subfamily Q, member 3|potassium voltage-gated channel KQT-like protein 3
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