KCNN4 purified MaxPab rabbit polyclonal antibody (D01P)
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More Files
- More Functions
Western Blot (Cell lysate)
KCNN4 MaxPab rabbit polyclonal antibody. Western Blot analysis of KCNN4 expression in THP-1.
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human KCNN4 protein.
Immunogen
KCNN4 (NP_002241.1, 1 a.a. ~ 427 a.a) full-length human protein.
Sequence
MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFLVKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPAPVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYRSIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHNFMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRKLREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLPEPSQQSK
Host
Rabbit
Reactivity
Human
Interspecies Antigen Sequence
Rat (86)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
KCNN4 MaxPab rabbit polyclonal antibody. Western Blot analysis of KCNN4 expression in THP-1. -
Gene Info — KCNN4
Entrez GeneID
3783GeneBank Accession#
NM_002250.2Protein Accession#
NP_002241.1Gene Name
KCNN4
Gene Alias
IK1, IKCA1, KCA4, KCa3.1, SK4, hIKCa1, hKCa4, hSK4
Gene Description
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
Omim ID
602754Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq
Other Designations
intermediate conductance calcium-activated potassium channel protein 1|putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel
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Interactome
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Disease
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Publication Reference
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The KCa3.1 blocker TRAM34 reverses renal damage in a mouse model of established diabetic nephropathy.
Huang C, Zhang L, Shi Y, Yi H, Zhao Y, Chen J, Pollock CA, Chen XM.
PLoS One 2018 Feb; 13:1.
Application：IHC-P, Mouse, Kidney.
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The KCa3.1 blocker TRAM34 reverses renal damage in a mouse model of established diabetic nephropathy.
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