KCNN3 polyclonal antibody (A01)
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More Files
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Specification
Product Description
Mouse polyclonal antibody raised against a partial recombinant KCNN3.
Immunogen
KCNN3 (NP_740752, 301 a.a. ~ 410 a.a) partial recombinant protein with GST tag.
Sequence
QAIHQLRSVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLSAIIEARGVSVAVGTTHTPISDSPIG
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (93)
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (38.21 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
KCNN3 polyclonal antibody (A01), Lot # 050921JC01 Western Blot analysis of KCNN3 expression in Y-79 ( Cat # L042V1 ).Western Blot (Recombinant protein)
ELISA
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Gene Info — KCNN3
Entrez GeneID
3782GeneBank Accession#
NM_170782Protein Accession#
NP_740752Gene Name
KCNN3
Gene Alias
KCa2.3, SK3, SKCA3, hSK3
Gene Description
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
Omim ID
602983Gene Ontology
HyperlinkGene Summary
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding two different isoforms have been found for this gene. One of the variants lacks the CAG repeat regions. [provided by RefSeq
Other Designations
OTTHUMP00000035369|OTTHUMP00000042458|OTTHUMP00000042459|small conductance calcium-activated potassium channel protein 3
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Interactome
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Disease
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Publication Reference
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Altered distribution of small-conductance calcium-activated potassium channel SK3 in Hirschsprung's disease.
Coyle D, O’Donnell AM, Puri P.
Journal of Pediatric Surgery 2015 Oct; 50(10):1659.
Application:IF, WB-Ce, Human, Colon sections, aganglionic specimen, ganglionic specimen, myenteric plexus.
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Pulmonary hypertension in wild type mice and animals with genetic deficit in KCa2.3 and KCa3.1 channels.
Wandall-Frostholm C, Skaarup LM, Sadda V, Nielsen G, Hedegaard ER, Mogensen S, Köhler R, Simonsen U.
PLoS One 2014 May; 9(5):e97687.
Application:WB-Ti, Mouse, Mouse lungs.
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Altered distribution of small-conductance calcium-activated potassium channel SK3 in Hirschsprung's disease.
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