KCNJ11 DNAxPab
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Specification
Product Description
Rabbit polyclonal antibody raised against a partial-length human KCNJ11 DNA using DNAx™ Immune technology.
Technology
Immunogen
Extracellular membrane domain (ECD) human DNA
Host
Rabbit
Reactivity
Human
Purification
Protein A
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Immunofluorescence (Transfected cell)
Flow Cytometry (Transfected cell)
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Gene Info — KCNJ11
Entrez GeneID
3767GeneBank Accession#
NM_000525.3Protein Accession#
NP_000516.3Gene Name
KCNJ11
Gene Alias
BIR, HHF2, IKATP, KIR6.2, MGC133230, PHHI, TNDM3
Gene Description
potassium inwardly-rectifying channel, subfamily J, member 11
Gene Ontology
HyperlinkGene Summary
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). [provided by RefSeq
Other Designations
ATP-sensitive inward rectifier potassium channel 11|beta-cell inward rectifier subunit|inwardly rectifying potassium channel KIR6.2|potassium inwardly-rectifying channel J11
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