Products

Western Blot (Recombinant protein)

ELISA

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

KCNJ1

Gene Alias

KIR1.1, ROMK, ROMK1

Gene Description

potassium inwardly-rectifying channel, subfamily J, member 1

Omim ID

Gene Ontology

Gene Summary

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Other Designations

ATP-regulated potassium channel ROM-K|ATP-sensitive inward rectifier potassium channel 1|OTTHUMP00000045938|inwardly rectifying K+ channel|potassium inwardly-rectifying channel J1