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KCNA1 rabbit monoclonal antibody

  • Catalog # : H00003736-K
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  • Specification
  • Product Description:
  • Rabbit monoclonal antibody raised against a human KCNA1 peptide using ARM Technology.
  • Immunogen:
  • A synthetic peptide of human KCNA1 is used for rabbit immunization.
    Customer or Abnova will decide on the preferred peptide sequence.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Purification:
  • Protein A
  • Isotype:
  • IgG
  • Quality Control Testing:
  • Antibody reactive against human KCNA1 peptide by ELISA and mammalian transfected lysate by Western Blot.
  • Storage Buffer:
  • In 1x PBS, pH 7.4
  • Storage Instruction:
  • Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • 1. Customer may provide cell or tissue lysate for antibody screening.
    2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.
  • Library Construction:
  • Non-fusion antibody library from rabbit spleen (ARM Technology).
  • Expression:
  • Overexpression vector and transfection into 293H cell line.
  • Deliverable:
  • Up to three rabbit IgG clones of 1 mg each will be delivered to customer.
  • Applications
  • Application Image
  • Western Blot (Transfected lysate)
  • Gene Information
  • Entrez GeneID:
  • 3736
  • GeneBank Accession#:
  • KCNA1
  • Gene Name:
  • KCNA1
  • Gene Alias:
  • AEMK,EA1,HBK1,HUK1,KV1.1,MBK1,MGC126782,MGC138385,MK1,RBK1
  • Gene Description:
  • potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
  • Gene Summary:
  • This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). [provided by RefSeq
  • Other Designations:
  • potassium voltage-gated channel subfamily A member 1,voltage-gated potassium channel subunit Kv1.1
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