ISL1 monoclonal antibody (M05), clone 2E7
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Western Blot (Cell lysate)
ISL1 monoclonal antibody (M05), clone 2E7 Western Blot analysis of ISL1 expression in PC-12 ( Cat # L012V1 ).
Immunofluorescence
Immunofluorescence of monoclonal antibody to ISL1 on HeLa cell. [antibody concentration 10 ug/ml]
Western Blot detection against Immunogen (36.41 KDa) .
-
Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant ISL1.
Immunogen
ISL1 (NP_002193, 63 a.a. ~ 159 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
YCKRDYIRLYGIKCAKCSIGFSKNDFVMRARSKVYHIECFRCVACSRQLIPGDEFALREDGLFCRADHDVVERASLGAGDPLSPLHPARPLQMAAEP
Host
Mouse
Reactivity
Human, Rat
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.41 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
-
Applications
Western Blot (Cell lysate)
ISL1 monoclonal antibody (M05), clone 2E7 Western Blot analysis of ISL1 expression in PC-12 ( Cat # L012V1 ).Western Blot (Recombinant protein)
ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to ISL1 on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — ISL1
Entrez GeneID
3670GeneBank Accession#
NM_002202Protein Accession#
NP_002193Gene Name
ISL1
Gene Alias
Isl-1
Gene Description
ISL LIM homeobox 1
Omim ID
600366Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq
Other Designations
ISL1 transcription factor, LIM/homeodomain|islet-1
-
Interactome
-
Disease
-
Publication Reference
-
Phosphorylation of islet-1 serine 269 by CDK1 increases its transcriptional activity and promotes cell proliferation in gastric cancer.
Qiong Shi, Xiaomei Ni, Ming Lei, Quansong Xia, Yan Dong, Qiao Zhang, Weiping Wang.
Molecular Immunology 2021 May; 27(1):47.
Application：IP, Human, MGC803 cells.
-
Cross-talk of SFRP4, integrin α1β1, and Notch1 inhibits cardiac differentiation of P19CL6 cells.
Tian Y, Wang W, Lu Q, Chen P, Ma K, Jia Z, Zhou C.
Cellular Signalling 2016 Nov; 28(11):1806.
Application：WB-Ce, WB-Tr, Human, P19CL6 cells.
-
ISL-1 is overexpressed in non-Hodgkin lymphoma and promotes lymphoma cell proliferation by forming a p-STAT3/p-c-Jun/ISL-1 complex.
Zhang Q, Yang Z, Jia Z, Liu C, Guo C, Lu H, Chen P, Ma K, Wang W, Zhou C.
Molecular Cancer 2014 Jul; 13:181.
Application：WB-Ce, WB-Tr, Human, SUDHL16, Raji, Ly3, Jurkat cells.
-
A positive feedback regulation of ISL-1 in DLBCL but not in pancreatic β-cells.
Zhang Q, Yang Z, Wang W, Guo T, Jia Z, Ma K, Zhou C.
Biochemical and Biophysical Research Communications 2014 Jul; 449(3):295.
Application：IP-WB, WB-Tr, Human, Mouse, HIT-T15, Ly3 cells.
-
Interaction of Wnt/?]-catenin and Notch signaling in the early stage of cardiac differentiation of P19CL6 cells.
Li B, Jia Z, Wang T, Wang W, Zhang C, Chen P, Ma K, Zhou C.
Journal of Cellular Biochemistry 2012 Feb; 113(2):629.
Application：WB-Ce, WB-Tr, Mouse, P19CL6 cells.
-
ISL1 Promotes Pancreatic Islet Cell Proliferation.
Guo T, Wang W, Zhang H, Liu Y, Chen P, Ma K, Zhou C.
PLoS One 2011 Aug; 6(8):e22387.
Application：Func, IP, WB-Tr, Mouse, HIT-T15 cells.
-
Phosphorylation of islet-1 serine 269 by CDK1 increases its transcriptional activity and promotes cell proliferation in gastric cancer.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com