Western blot analysis of ISL1 over-expressed 293 cell line, cotransfected with ISL1 Validated Chimera RNAi ( Cat # H00003670-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with ISL1 monoclonal antibody (M01), clone 1A3 (Cat # H00003670-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq