IRF3 MaxPab mouse polyclonal antibody (B01)
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More Files
- More Functions
Western Blot (Tissue lysate)
IRF3 MaxPab polyclonal antibody. Western Blot analysis of IRF3 expression in human placenta.
Western Blot (Transfected lysate)
Western Blot analysis of IRF3 expression in transfected 293T cell line (H00003661-T01) by IRF3 MaxPab polyclonal antibody.
Lane 1: IRF3 transfected lysate(46.97 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to IRF3 on HeLa cell. [antibody concentration 10 ug/ml]
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human IRF3 protein.
Immunogen
IRF3 (NP_001562.1, 1 a.a. ~ 427 a.a) full-length human protein.
Sequence
MGTPKPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQEDFGIFQAWAEATGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSKDPHDPHKIYEFVNSGVGDFSQPDTSPDTNGGGSTSDTQEDILDELLGNMVLAPLPDPGPPSLAVAPEPCPQPLRSPSLDNPTPFPNLGPSENPLKRLLVPGEEWEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDRTLPGWPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLGHCHTYWAVSEELLPNSGHGPDGEVPKDKEGGVFDLGPFIVDLITFTEGSGRSPRYALWFCVGESWPQDQPWTKRLVMVKVVPTCLRALVEMARVGGASSLENTVDLHISNSHPLSLTSDQYKAYLQDLVEGMDFQGPGES
Host
Mouse
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
No additive
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Note
For IHC and IF applications, antibody purification with Protein A will be needed prior to use.
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Applications
Western Blot (Tissue lysate)
IRF3 MaxPab polyclonal antibody. Western Blot analysis of IRF3 expression in human placenta.Western Blot (Transfected lysate)
Western Blot analysis of IRF3 expression in transfected 293T cell line (H00003661-T01) by IRF3 MaxPab polyclonal antibody.
Lane 1: IRF3 transfected lysate(46.97 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to IRF3 on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — IRF3
Entrez GeneID
3661GeneBank Accession#
NM_001571.2Protein Accession#
NP_001562.1Gene Name
IRF3
Gene Alias
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Gene Description
interferon regulatory factor 3
Omim ID
603734Gene Ontology
HyperlinkGene Summary
IRF3 encodes interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. [provided by RefSeq
Other Designations
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Interactome
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Pathway
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Disease
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Publication Reference
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The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity.
Adam Hage, Preeti Bharaj, Sarah van Tol, Maria I Giraldo, Maria Gonzalez-Orozco, Karl M Valerdi, Abbey N Warren, Leopoldo Aguilera-Aguirre, Xuping Xie, Steven G Widen, Hong M Moulton, Benhur Lee, Jeffrey R Johnson, Nevan J Krogan, Adolfo García-Sastre, Pei-Yong Shi, Alexander N Freiberg, Ricardo Rajsbaum.
Cell Reports 2022 Mar; 38(10):110434.
Application：WB-Tr, Human, A-549 cells.
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The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity.
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