PDX1 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-PDX1 full-length
Host
Human
Theoretical MW (kDa)
31.13
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-PDX1 antibody (H00003651-D01P) by Western Blots.
SDS-PAGE Gel
PDX1 transfected lysate.
Western Blot
Lane 1: PDX1 transfected lysate ( 31.13 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — PDX1
Entrez GeneID
3651GeneBank Accession#
BC111592Protein Accession#
AAI11593.1Gene Name
PDX1
Gene Alias
GSF, IDX-1, IPF1, IUF1, MODY4, PDX-1, STF-1
Gene Description
pancreatic and duodenal homeobox 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq
Other Designations
OTTHUMP00000018174|glucose-sensitive factor|insulin promoter factor 1, homeodomain transcription factor|insulin upstream factor 1|pancreatic-duodenal homeobox factor 1|somatostatin transcription factor 1
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Interactome
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Disease
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