PDX1 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human PDX1 full-length ORF ( AAI11593.1, 1 a.a. - 283 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MNGEEQYYAATQLYKDPCAFQRGPAPEFSASPPACLYMGRQPPPPPPHPFPGALGALEQGSPPDISPYEVPPLADDPAVAHLHHHLPAQLALPHPPAGPFPEGAEPGVLEEPNRVQLPFPWMKSTKAHAWKGQWAGGAYAAEPEENKRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKWKKEEDKKRGGGTAVGGGGVAEPEQDCAVTSGEELLALPPPPPPGGAVPPAAPVAAREGRLPPGLSASPQPSSVAPRRPQEPR
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
58.08
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — PDX1
Entrez GeneID
3651GeneBank Accession#
BC111592Protein Accession#
AAI11593.1Gene Name
PDX1
Gene Alias
GSF, IDX-1, IPF1, IUF1, MODY4, PDX-1, STF-1
Gene Description
pancreatic and duodenal homeobox 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq
Other Designations
OTTHUMP00000018174|glucose-sensitive factor|insulin promoter factor 1, homeodomain transcription factor|insulin upstream factor 1|pancreatic-duodenal homeobox factor 1|somatostatin transcription factor 1
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Interactome
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Pathway
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Disease
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