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INPP5D Pre-design Chimera RNAi

  • Catalog # : H00003635-R01
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Homo sapiens inositol polyphosphate-5-phosphatase, 145kDa (INPP5D), transcript variant 1, mRNA.
  • Reactivity:
  • Human
  • Supplied Product:
  • DEPC water
  • Target Refseq:
  • NM_001017915
  • Storage Instruction:
  • Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
  • Note:
  • Position of the Chimera RNAi.
    The related RNAi products listed below were designed from different accesion number but sharing the same RNAi sequence.

  • Publication Reference
  • Applications
  • RNAi Knockdown
  • Application Image
  • RNAi Knockdown
  • Gene Information
  • Entrez GeneID:
  • 3635
  • Gene Name:
  • INPP5D
  • Gene Alias:
  • MGC104855,MGC142140,MGC142142,SHIP,SHIP1,SIP-145,hp51CN
  • Gene Description:
  • inositol polyphosphate-5-phosphatase, 145kDa
  • Gene Summary:
  • This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
  • Other Designations:
  • SH2 containing inositol phosphatase,SH2 containing inositol phosphatase, isoform b,p150Ship,signaling inositol polyphosphate 5 phosphatase SIP-145
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