ING1 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human ING1 full-length ORF ( NP_937862.1, 1 a.a. - 279 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MLSPANGEQLHLVNYVEDYLDSIESLPFDLQRNVSLMREIDAKYQEILKELDECYERFSRETDGAQKRRMLHCVQRALIRSQELGDEKIQIVSQMVELVENRTRQVDSHVELFEAQQELGDTAGNSGKAGADRPKGEAAAQADKPNSKRSRRQRNNENRENASSNHDHDDGASGTPKEKKAKTSKKKKRSKAKAEREASPADLPIDPNEPTYCLCNQVSYGEMIGCDNDECPIEWFHFSCVGLNHKPKGKWYCPKCRGENEKTMDKALEKSKKERAYNR
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
58.3
Interspecies Antigen Sequence
Mouse (90); Rat (89)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — ING1
Entrez GeneID
3621GeneBank Accession#
NM_198219.1Protein Accession#
NP_937862.1Gene Name
ING1
Gene Alias
p24ING1c, p33, p33ING1, p33ING1b, p47, p47ING1a
Gene Description
inhibitor of growth family, member 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
OTTHUMP00000018703|OTTHUMP00000018704|OTTHUMP00000018705|OTTHUMP00000018706|growth inhibitor ING1|growth inhibitory protein ING1|inhibitor of growth 1|tumor suppressor ING1
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Interactome
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Disease
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