IMPDH2 (Human) Recombinant Protein (P01)
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Specification
Product Description
Human IMPDH2 full-length ORF ( AAH12840, 1 a.a. - 514 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMTKREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
82.17
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — IMPDH2
Entrez GeneID
3615GeneBank Accession#
BC012840Protein Accession#
AAH12840Gene Name
IMPDH2
Gene Alias
IMPD2, IMPDH-II
Gene Description
IMP (inosine monophosphate) dehydrogenase 2
Omim ID
146691Gene Ontology
HyperlinkGene Summary
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq
Other Designations
IMP dehydrogenase 2|IMP oxireductase 2|inosine 5' phosphate dehydrogenase 2|inosine monophosphate dehydrogenase 2|inosine monophosphate dehydrogenase type II|inosine monophosphate oxireductase 2
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Interactome
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Pathway
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Disease
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Publication Reference
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Relationship between circulating tumor-associated autoantibodies and clinical outcomes in advanced-stage NSCLC patients receiving PD-1/-L1 directed immune checkpoint inhibition.
Imad Tarhoni, Connor J Wakefield, Revathi Kollipara, Mary Jo Fidler, Marta Batus, Philip Bonomi, Jeffrey A Borgia.
Journal of Immunological Methods 2021 Jan; 490:112956.
Application：Conjugation, Human, Beads, Human serum.
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Reference standards for the detection of anti-mitochondrial and anti-rods/rings autoantibodies.
Calise SJ, Zheng B, Hasegawa T, Satoh M, Isailovic N, Ceribelli A, Andrade LEC, Boylan K, Cavazzana I, Fritzler MJ, de la Torre IG, Hiepe F, Kohl K, Selmi C, Shoenfeld Y, Tincani A, Chan EKL; IUIS Autoantibody Standardization Committee.
Clinical Chemistry and Laboratory Medicine 2018 Feb; [Epub].
Application：LIA, ALBIA, ELISA, Human, Plasma.
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Relationship between circulating tumor-associated autoantibodies and clinical outcomes in advanced-stage NSCLC patients receiving PD-1/-L1 directed immune checkpoint inhibition.
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