IMPDH2 purified MaxPab rabbit polyclonal antibody (D01P)
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human IMPDH2 protein.
Immunogen
IMPDH2 (NP_000875.2, 1 a.a. ~ 514 a.a) full-length human protein.
Sequence
MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMTKREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
Host
Rabbit
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of IMPDH2 expression in transfected 293T cell line (H00003615-T01) by IMPDH2 MaxPab polyclonal antibody.
Lane 1: IMPDH2 transfected lysate(55.80 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to IMPDH2 on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — IMPDH2
Entrez GeneID
3615GeneBank Accession#
NM_000884.2Protein Accession#
NP_000875.2Gene Name
IMPDH2
Gene Alias
IMPD2, IMPDH-II
Gene Description
IMP (inosine monophosphate) dehydrogenase 2
Omim ID
146691Gene Ontology
HyperlinkGene Summary
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq
Other Designations
IMP dehydrogenase 2|IMP oxireductase 2|inosine 5' phosphate dehydrogenase 2|inosine monophosphate dehydrogenase 2|inosine monophosphate dehydrogenase type II|inosine monophosphate oxireductase 2
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Interactome
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Pathway
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Disease
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