IL12A monoclonal antibody (M02), clone 1A6
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant IL12A.
Immunogen
IL12A (NP_000873.2, 144 a.a. ~ 253 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
CLASRKTSFMMALCLSSIYEDLKMYQVEFKTMNAKLLMDPKRQIFLDQNMLAVIDELMQALNFNSETVPQKSSLEEPDFYKTKIKLCILLHAFRIRAVTIDRVMSYLNAS
Host
Mouse
Reactivity
Human
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.62 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of IL12A expression in transfected 293T cell line by IL12A monoclonal antibody (M02), clone 1A6.
Lane 1: IL12A transfected lysate (Predicted MW: 28.3 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
ELISA
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Gene Info — IL12A
Entrez GeneID
3592GeneBank Accession#
NM_000882Protein Accession#
NP_000873.2Gene Name
IL12A
Gene Alias
CLMF, IL-12A, NFSK, NKSF1, P35
Gene Description
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
Omim ID
161560Gene Ontology
HyperlinkGene Summary
This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq
Other Designations
IL-12, subunit p35|NF cell stimulatory factor chain 1|cytotoxic lymphocyte maturation factor 1, p35|interleukin 12, p35|interleukin 12A|interleukin-12 alpha chain|natural killer cell stimulatory factor 1, 35 kD subunit
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Interactome
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Pathway
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Disease
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