IL10RA 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-IL10RA full-length
Host
Human
Theoretical MW (kDa)
62.9
Interspecies Antigen Sequence
Mouse (56); Rat (56)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-IL10RA antibody (H00003587-B01) by Western Blots.
SDS-PAGE Gel
IL10RA transfected lysate.
Western Blot
Lane 1: IL10RA transfected lysate ( 62.9 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — IL10RA
Entrez GeneID
3587GeneBank Accession#
NM_001558.2Protein Accession#
NP_001549.1Gene Name
IL10RA
Gene Alias
CDW210A, HIL-10R, IL-10R1, IL10R
Gene Description
interleukin 10 receptor, alpha
Omim ID
146933Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq
Other Designations
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