CXCR1 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human CXCR1 full-length ORF ( AAH28221.1, 1 a.a. - 350 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MSNITDPQMWDFDDLNFTGMPPADEDYSPCRLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHCVTSYTSSSVNVSSNL
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
64.24
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — CXCR1
Entrez GeneID
3577GeneBank Accession#
BC028221Protein Accession#
AAH28221.1Gene Name
CXCR1
Gene Alias
C-C, C-C-CKR-1, CD128, CD181, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA
Gene Description
chemokine (C-X-C motif) receptor 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq
Other Designations
receptor|alpha|interleukin-8 receptor type 1|interleukin-8 receptor type A
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Interactome
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Pathway
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Disease
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Publication Reference
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Identification of amino acid residues critical for the B cell growth-promoting activity of HIV-1 matrix protein p17 variants.
He W, Mazzuca P, Yuan W, Varney K, Bugatti A, Cagnotto A, Giagulli C, Rusnati M, Marsico S, Diomede L, Salmona M, Caruso A, Lu W, Caccuri F.
Biochimica et Biophysica acta. General Subjects 2018 Sep; 863(1):13.
Application:Func, Peptides.
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{alpha}-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8.
Bergin DA, Reeves EP, Meleady P, Henry M, McElvaney OJ, Carroll TP, Condron C, Chotirmall SH, Clynes M, O'Neill SJ, McElvaney NG.
The Journal of Clinical Investigation 2010 Dec; 120(12):4236.
Application:PI, Human, Recombinant protein.
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Identification of amino acid residues critical for the B cell growth-promoting activity of HIV-1 matrix protein p17 variants.
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