IL7R DNAxPab
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Specification
Product Description
Rabbit polyclonal antibody raised against a partial-length human IL7R DNA using DNAx™ Immune technology.
Technology
Immunogen
Extracellular membrane domain (ECD) human DNA
Host
Rabbit
Reactivity
Human
Purification
Protein A
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Immunofluorescence (Transfected cell)
Flow Cytometry (Transfected cell)
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Gene Info — IL7R
Entrez GeneID
3575GeneBank Accession#
BC067539.1Protein Accession#
AAH67539.1Gene Name
IL7R
Gene Alias
CD127, CDW127, IL-7R-alpha, IL7RA, ILRA
Gene Description
interleukin 7 receptor
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). [provided by RefSeq
Other Designations
CD127 antigen|interleukin 7 receptor alpha chain
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Interactome
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Pathway
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Disease
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