IL7R 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-IL7R full-length
Host
Human
Theoretical MW (kDa)
50.6
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-IL7R antibody (H00003575-B01) by Western Blots.
Western Blot
Lane 1: IL7R transfected lysate ( 51.5 KDa)
Lane 2: Non-transfected lysate.SDS-PAGE Gel
IL7R transfected lysate.
Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — IL7R
Entrez GeneID
3575GeneBank Accession#
BC067539Protein Accession#
AAH67539Gene Name
IL7R
Gene Alias
CD127, CDW127, IL-7R-alpha, IL7RA, ILRA
Gene Description
interleukin 7 receptor
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). [provided by RefSeq
Other Designations
CD127 antigen|interleukin 7 receptor alpha chain
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