IL1RAP monoclonal antibody (M06), clone 2A3
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More Files
- More Functions
Immunoprecipitation
Immunoprecipitation of IL1RAP transfected lysate using anti-IL1RAP monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with IL1RAP MaxPab rabbit polyclonal antibody.
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged IL1RAP is 0.3 ng/ml as a capture antibody.
Western Blot detection against Immunogen (64.9 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a full-length recombinant IL1RAP.
Immunogen
IL1RAP (AAH53621.1, 1 a.a. ~ 356 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYSTAHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTPTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKGNRCGQ
Host
Mouse
Reactivity
Human
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (64.9 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Immunoprecipitation
Immunoprecipitation of IL1RAP transfected lysate using anti-IL1RAP monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with IL1RAP MaxPab rabbit polyclonal antibody.Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged IL1RAP is 0.3 ng/ml as a capture antibody.ELISA
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Gene Info — IL1RAP
Entrez GeneID
3556GeneBank Accession#
BC053621Protein Accession#
AAH53621.1Gene Name
IL1RAP
Gene Alias
C3orf13, FLJ37788, IL-1RAcP, IL1R3
Gene Description
interleukin 1 receptor accessory protein
Omim ID
602626Gene Ontology
HyperlinkGene Summary
Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes an interleukin 1 receptor accessory protein. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. [provided by RefSeq
Other Designations
interleukin-1 receptor accessory protein beta
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Interactome
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Pathway
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Disease
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Publication Reference
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IL1RAP potentiates multiple oncogenic signaling pathways in AML.
Mitchell K, Barreyro L, Todorova TI, Taylor SJ, Antony-Debré I, Narayanagari SR, Carvajal LA, Leite J, Piperdi Z, Pendurti G, Mantzaris I, Paietta E, Verma A, Gritsman K, Steidl U.
The Journal of Experimental Medicine 2018 Jun; 215(6):1709.
Application：Teatment, Human, THP-1 cells.
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IL1RAP potentiates multiple oncogenic signaling pathways in AML.
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