IGL 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-IGL full-length
Host
Human
Theoretical MW (kDa)
24.8
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-IGL antibody (H00003535-B01P) by Western Blots.
SDS-PAGE Gel
IGL@ transfected lysate.
Western Blot
Lane 1: IGL@ transfected lysate ( 24.80 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — IGL@
Entrez GeneID
3535GeneBank Accession#
BC089414Protein Accession#
AAH89414.1Gene Name
IGL@
Gene Alias
IGL, MGC88804
Gene Description
immunoglobulin lambda locus
Gene Ontology
HyperlinkGene Summary
Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two classes of light chains, kappa and lambda. This region represents the germline organization of the lambda light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Several V segments and three C segments are known to be incapable of encoding a protein and are considered pseudogenes. The locus also includes several non-immunoglobulin genes, many of which are pseudogenes or are predicted by automated computational analysis or homology to other species. [provided by RefSeq
Other Designations
immunoglobulin lambda gene cluster
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