Immunoprecipitation of IDS transfected lysate using anti-IDS MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with IDS MaxPab rabbit polyclonal antibody (D01) (H00003423-D01).
Iduronate-2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X-chromosome gene that result in enzymatic deficiency lead to the sex-linked Mucopolysaccharidosis Type II, also known as Hunter Syndrome. Iduronate-2-sulfatase has a strong sequence homology with human arylsulfatases A, B, and C, and human glucosamine-6-sulfatase. A splice variant of this gene has been described. [provided by RefSeq