IDS polyclonal antibody (A01)
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Specification
Product Description
Mouse polyclonal antibody raised against a partial recombinant IDS.
Immunogen
IDS (NP_000193, 38 a.a. ~ 137 a.a) partial recombinant protein with GST tag.
Sequence
NVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVF
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (97)
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.11 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
ELISA
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Gene Info — IDS
Entrez GeneID
3423GeneBank Accession#
NM_000202Protein Accession#
NP_000193Gene Name
IDS
Gene Alias
MPS2, SIDS
Gene Description
iduronate 2-sulfatase
Omim ID
309900Gene Ontology
HyperlinkGene Summary
Iduronate-2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X-chromosome gene that result in enzymatic deficiency lead to the sex-linked Mucopolysaccharidosis Type II, also known as Hunter Syndrome. Iduronate-2-sulfatase has a strong sequence homology with human arylsulfatases A, B, and C, and human glucosamine-6-sulfatase. A splice variant of this gene has been described. [provided by RefSeq
Other Designations
Hunter syndrome|OTTHUMP00000024207|OTTHUMP00000024210|alpha-L-iduronate sulfate sulfatase|iduronate-2-sulfatase|idursulfase
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Interactome
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Pathway
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Disease
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Publication Reference
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In Vitro recapitulation of the site-specific editing (to Wild-Type) of mutant IDS mRNA transcripts, and characterization of IDS protein translated from the edited mRNAs.
Lualdi S, Zotto GD, Zegarra-Moran O, Pedemonte N, Corsolini F, Bruschi M, Tomati V, Amico G, Candiano G, Dardis A, Cooper DN, Filocamo M.
Human Mutation 2017 Jul; 38(7):849.
Application:WB, IP, Human, Lymphoblasts from Hunter syndrome patients.
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In Vitro recapitulation of the site-specific editing (to Wild-Type) of mutant IDS mRNA transcripts, and characterization of IDS protein translated from the edited mRNAs.
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