ID4 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human ID4 full-length ORF ( NP_001537.1, 1 a.a. - 161 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MKAVSPVRPSGRKAPSGCGGGELALRCLAEHGHSLGGSAAAAAAAAAARCKAAEAAADEPALCLQCDMNDCYSRLRRLVPTIPPNKKVSKVEILQHVIDYILDLQLALETHPALLRQPPPPAPPHHPAGTCPAAPPRTPLTALNTDPAGAVNKQGDSILCR
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
43
Interspecies Antigen Sequence
Mouse (98)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — ID4
Entrez GeneID
3400GeneBank Accession#
NM_001546.2Protein Accession#
NP_001537.1Gene Name
ID4
Gene Alias
IDB4, bHLHb27
Gene Description
inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
Omim ID
600581Gene Ontology
HyperlinkGene Summary
Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. DNA-binding activity of the bHLH proteins is dependent on formation of homo- and/or heterodimers. Dominant-negative HLH proteins encoded by Id-related genes, such as ID4, also contain the HLH-dimerization domain but lack the DNA-binding basic domain. Consequently, Id proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins (Pagliuca et al., 1995 [PubMed 7665172]).[supplied by OMIM
Other Designations
OTTHUMP00000016081
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Interactome
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Pathway
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