IAPP DNAxPab
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human IAPP DNA using DNAx™ Immune technology.
Technology
Immunogen
Full-length human DNA
Sequence
MGILKLQVFLIVLSVALNHLKATPIESHQVEKRKCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTYGKRNAVEVLKREPLNYLPL
Host
Rabbit
Reactivity
Human
Purification
Protein A
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Immunofluorescence (Transfected cell)
Flow Cytometry (Transfected cell)
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Gene Info — IAPP
Entrez GeneID
3375GeneBank Accession#
NM_000415.1Protein Accession#
NP_000406.1Gene Name
IAPP
Gene Alias
AMYLIN, DAP, IAP
Gene Description
islet amyloid polypeptide
Omim ID
147940Gene Ontology
HyperlinkGene Summary
Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the assosciation of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Studies suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. [provided by RefSeq
Other Designations
Islet amyloid polypeptide (diabetes-associated peptide; amylin)
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Interactome
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Pathway
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Disease
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