IAPP (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human IAPP full-length ORF ( NP_000406.1, 1 a.a. - 89 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MGILKLQVFLIVLSVALNHLKATPIESHQVEKRKCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTYGKRNAVEVLKREPLNYLPL
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
36.2
Interspecies Antigen Sequence
Mouse (67); Rat (66)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — IAPP
Entrez GeneID
3375GeneBank Accession#
NM_000415.1Protein Accession#
NP_000406.1Gene Name
IAPP
Gene Alias
AMYLIN, DAP, IAP
Gene Description
islet amyloid polypeptide
Omim ID
147940Gene Ontology
HyperlinkGene Summary
Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the assosciation of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Studies suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. [provided by RefSeq
Other Designations
Islet amyloid polypeptide (diabetes-associated peptide; amylin)
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Interactome
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Pathway
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Disease
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