IAPP purified MaxPab rabbit polyclonal antibody (D01P)
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human IAPP protein.
Immunogen
IAPP (NP_000406.1, 1 a.a. ~ 89 a.a) full-length human protein.
Sequence
MGILKLQVFLIVLSVALNHLKATPIESHQVEKRKCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTYGKRNAVEVLKREPLNYLPL
Host
Rabbit
Reactivity
Human
Interspecies Antigen Sequence
Mouse (67); Rat (66)
Quality Control Testing
Antibody reactive against mammalian tissue lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — IAPP
Entrez GeneID
3375GeneBank Accession#
NM_000415Protein Accession#
NP_000406.1Gene Name
IAPP
Gene Alias
AMYLIN, DAP, IAP
Gene Description
islet amyloid polypeptide
Omim ID
147940Gene Ontology
HyperlinkGene Summary
Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the assosciation of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Studies suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. [provided by RefSeq
Other Designations
Islet amyloid polypeptide (diabetes-associated peptide; amylin)
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Interactome
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Pathway
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Disease
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