HUS1 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Western Blot
Lane 1: HUS1 transfected lysate ( 31.7 KDa)
Lane 2: Non-transfected lysate.
SDS-PAGE Gel
HUS1 transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-HUS1 full-length
Host
Human
Theoretical MW (kDa)
30.91
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-HUS1 antibody (H00003364-B01) by Western Blots.
Western Blot
Lane 1: HUS1 transfected lysate ( 31.7 KDa)
Lane 2: Non-transfected lysate.SDS-PAGE Gel
HUS1 transfected lysate.
Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — HUS1
Entrez GeneID
3364GeneBank Accession#
NM_004507Protein Accession#
NP_004498Gene Name
HUS1
Gene Alias
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Gene Description
HUS1 checkpoint homolog (S. pombe)
Omim ID
603760Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. [provided by RefSeq
Other Designations
HUS1 checkpoint protein|hus1+-like protein
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Interactome
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Disease
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