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HTR2C (Human) Recombinant Protein (Q01)

  • Catalog # : H00003358-Q01
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  • Specification
  • Product Description:
  • Human HTR2C partial ORF ( NP_000859, 1 a.a. - 52 a.a.) recombinant protein with GST-tag at N-terminal.
  • Sequence:
  • MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGV
  • Host:
  • Wheat Germ (in vitro)
  • Theoretical MW (kDa):
  • 31.46
  • Purification:
  • Glutathione Sepharose 4 Fast Flow
  • Quality Control Testing:
  • 12.5% SDS-PAGE Stained with Coomassie Blue.

    QC Testing of H00003358-Q01
  • Storage Buffer:
  • 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Note:
  • Best use within three months from the date of receipt of this protein.
  • Applications
  • Enzyme-linked Immunoabsorbent Assay
  • Western Blot (Recombinant protein)
  • Antibody Production
  • Protein Array
  • Application Image
  • Enzyme-linked Immunoabsorbent Assay
  • Western Blot (Recombinant protein)
  • Antibody Production
  • Protein Array
  • Gene Information
  • Entrez GeneID:
  • 3358
  • Gene Name:
  • HTR2C
  • Gene Alias:
  • 5-HT2C,5-HTR2C,HTR1C
  • Gene Description:
  • 5-hydroxytryptamine (serotonin) receptor 2C
  • Gene Summary:
  • Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. [provided by RefSeq
  • Other Designations:
  • 5-hydroxytryptamine receptor 2C,OTTHUMP00000023868,OTTHUMP00000023869,serotonin 5-HT-2C receptor,serotonin receptor 2C
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