HTR2C monoclonal antibody (M02), clone 1A8
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant HTR2C.
Immunogen
HTR2C (NP_000859, 1 a.a. ~ 52 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGV
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (81); Rat (81)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (31.46 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged HTR2C is approximately 0.1ng/ml as a capture antibody.ELISA
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Gene Info — HTR2C
Entrez GeneID
3358GeneBank Accession#
NM_000868Protein Accession#
NP_000859Gene Name
HTR2C
Gene Alias
5-HT2C, 5-HTR2C, HTR1C
Gene Description
5-hydroxytryptamine (serotonin) receptor 2C
Omim ID
312861Gene Ontology
HyperlinkGene Summary
Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. [provided by RefSeq
Other Designations
5-hydroxytryptamine receptor 2C|OTTHUMP00000023868|OTTHUMP00000023869|serotonin 5-HT-2C receptor|serotonin receptor 2C
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Interactome
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Disease
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