HSPA5 polyclonal antibody (A01)
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More Files
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Western Blot (Cell lysate)
HSPA5 polyclonal antibody (A01), Lot # 050920JC01 Western Blot analysis of HSPA5 expression in MES-SA/Dx5 ( Cat # L021V1 ).
Western Blot detection against Immunogen (96.07 KDa) .
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length recombinant HSPA5.
Immunogen
HSPA5 (AAH20235.1, 19 a.a. ~ 654 a.a) full-length recombinant protein with GST tag.
Sequence
EEEDKKEDVGTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALSSQHQARIEIESFYEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGDLVLLDVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLGTFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIERMVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEEKIEWLESHQDADIEDFKAKKKELEEIVQPIISKLYGSAGPPPTGEEDTAEKDEL
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (99); Rat (99)
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (96.07 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
HSPA5 polyclonal antibody (A01), Lot # 050920JC01 Western Blot analysis of HSPA5 expression in MES-SA/Dx5 ( Cat # L021V1 ).Western Blot (Recombinant protein)
ELISA
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Gene Info — HSPA5
Entrez GeneID
3309GeneBank Accession#
BC020235Protein Accession#
AAH20235.1Gene Name
HSPA5
Gene Alias
BIP, FLJ26106, GRP78, MIF2
Gene Description
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
Omim ID
138120Gene Ontology
HyperlinkGene Summary
When Chinese hamster K12 cells are starved of glucose, the synthesis of several proteins, called glucose-regulated proteins (GRPs), is markedly increased. Hendershot et al. (1994) [PubMed 8020977] pointed out that one of these, GRP78 (HSPA5), also referred to as 'immunoglobulin heavy chain-binding protein' (BiP), is a member of the heat-shock protein-70 (HSP70) family and is involved in the folding and assembly of proteins in the endoplasmic reticulum (ER). Because so many ER proteins interact transiently with GRP78, it may play a key role in monitoring protein transport through the cell.[supplied by OMIM
Other Designations
Heat-shock 70kD protein-5 (glucose-regulated protein, 78kD)|OTTHUMP00000022124|heat shock 70kD protein 5 (glucose-regulated protein, 78kD)|heat shock 70kDa protein 5
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Interactome
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Pathway
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Disease
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Publication Reference
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GRP-78 secreted by tumor cells blocks the anti-angiogenic activity of bortezomib.
Kern J, Untergasser G, Zenzmaier C, Sarg B, Gastl G, Gunsilius E, Steurer M.
Blood 2009 Oct; 114(18):3960.
Application：WB-Tr, Human, PC-3 cells.
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Proteinuria and Hyperglycemia Induce Endoplasmic Reticulum Stress.
Lindenmeyer MT, Rastaldi MP, Ikehata M, Neusser MA, Kretzler M, Cohen CD, Schlondorff D.
Journal of the American Society of Nephrology 2008 Sep; 19(11):2225.
Application：IF, Human, Normal kidneys or from patients with established diabetic nephropathy (DN) or minimal-change disease (MCD).
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GRP-78 secreted by tumor cells blocks the anti-angiogenic activity of bortezomib.
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