HSD11B1 purified MaxPab rabbit polyclonal antibody (D01P)
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human HSD11B1 protein.
Immunogen
HSD11B1 (NP_005516.1, 1 a.a. ~ 292 a.a) full-length human protein.
Sequence
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
Host
Rabbit
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
HSD11B1 MaxPab rabbit polyclonal antibody. Western Blot analysis of HSD11B1 expression in human liver.Western Blot (Transfected lysate)
Western Blot analysis of HSD11B1 expression in transfected 293T cell line (H00003290-T01) by HSD11B1 MaxPab polyclonal antibody.
Lane 1: HSD11B1 transfected lysate(32.40 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — HSD11B1
Entrez GeneID
3290GeneBank Accession#
NM_005525.2Protein Accession#
NP_005516.1Gene Name
HSD11B1
Gene Alias
11-DH, 11-beta-HSD1, HDL, HSD11, HSD11B, HSD11L, MGC13539, SDR26C1
Gene Description
hydroxysteroid (11-beta) dehydrogenase 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
11-beta-hydroxysteroid dehydrogenase 1|OTTHUMP00000034649|OTTHUMP00000034650|corticosteroid 11-beta-dehydrogenase isozyme 1|short chain dehydrogenase/reductase family 26C, member 1
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Interactome
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