Immunoprecipitation of HRG transfected lysate using anti-HRG MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with HRG purified MaxPab mouse polyclonal antibody (B01P) (H00003273-B01P).
This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels. [provided by RefSeq
histidine-proline rich glycoprotein,thrombophilia due to elevated HRG