HRG purified MaxPab mouse polyclonal antibody (B01P)
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More Files
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human HRG protein.
Immunogen
HRG (NP_000403, 1 a.a. ~ 525 a.a) full-length human protein.
Sequence
MKALIAALLLITLQYSCAVSPTDCSAVEPEAEKALDLINKRRRDGYLFQLLRIADAHLDRVENTTVYYLVLDVQESDCSVLSRKYWNDCEPPDSRRPSEIVIGQCKVIATRHSHESQDLRVIDFNCTTSSVSSALANTKDSPVLIDFFEDTERYRKQANKALEKYKEENDDFASFRVDRIERVARVRGGEGTGYFVDFSVRNCPRHHFPRHPNVFGFCRADLFYDVEALDLESPKNLVINCEVFDPQEHENINGVPPHLGHPFHWGGHERSSTTKPPFKPHGSRDHHHPHKPHEHGPPPPPDERDHSHGPPLPQGPPPLLPMSCSSCQHATFGTNGAQRHSHNNNSSDLHPHKHHSHEQHPHGHHPHAHHPHEHDTHRQHPHGHHPHGHHPHGHHPHGHHPHGHHPHCHDFQDYGPCDPPPHNQGHCCHGHGPPPGHLRRRGPGKGPRPFHCRQIGSVYRLPPLRKGEVLPLPEANFPSFPLPHHKHPLKPDNQPFPQSVSESCPGKFKSGFPQVSMFFTHTFPK
Host
Mouse
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of HRG expression in transfected 293T cell line (H00003273-T01) by HRG MaxPab polyclonal antibody.
Lane 1: HRG transfected lysate(57.75 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — HRG
Entrez GeneID
3273GeneBank Accession#
NM_000412Protein Accession#
NP_000403Gene Name
HRG
Gene Alias
DKFZp779H1622, HPRG, HRGP
Gene Description
histidine-rich glycoprotein
Omim ID
142640Gene Ontology
HyperlinkGene Summary
This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels. [provided by RefSeq
Other Designations
histidine-proline rich glycoprotein|thrombophilia due to elevated HRG
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Interactome
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Disease
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Publication Reference
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Histidine-rich glycoprotein uptake and turnover is mediated by mononuclear phagocytes.
Tugues S, Roche F, Noguer O, Orlova A, Bhoi S, Padhan N, Akerud P, Honjo S, Selvaraju RK, Mazzone M, Tolmachev V, Claesson-Welsh L.
PLoS One 2014 Sep; 9(9):e107483.
Application:ELISA, Human, Plasma.
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Prediction of preeclampsia by combining serum histidine-rich glycoprotein and uterine artery Doppler.
Bolin M, Wikström AK, Wiberg-Itzel E, Olsson AK, Ringvall M, Sundström-Poromaa I, Axelsson O, Thilaganathan B, Åkerud H.
American Journal of Hypertension 2012 Dec; 25(12):1305.
Application:ELISA, Human, Plasma from patients with preterm preeclampsia.
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Histidine-Rich Glycoprotein as an Early Biomarker of Preeclampsia.
Bolin M, Akerud P, Hansson A, Akerud H.
American Journal of Hypertension 2011 Apr; 24(4):496.
Application:ELISA, Human, Plasma.
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The Presence of Histidine-Rich Glycoprotein in the Female Reproductive Tract and in Embryos.
Nordqvist S, Karehed K, Hambiliki F, Wanggren K, Stavreus-Evers A, Akerud H.
Reproductive Sciences (Thousand Oaks, Calif.) 2010 Jul; 17(10):941.
Application:ELISA, Human, Human preimplantation embryos.
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Histidine-rich glycoprotein uptake and turnover is mediated by mononuclear phagocytes.
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