Western blot analysis of HOXB7 over-expressed 293 cell line, cotransfected with HOXB7 Validated Chimera RNAi ( Cat # H00003217-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with HOXB7 monoclonal antibody (M04), clone 5B2 (Cat # H00003217-M04 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma. [provided by RefSeq