HOXB5 (Human) Recombinant Protein (P01)
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More Files
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Specifications
Product Description
Human HOXB5 full-length ORF ( NP_002138.1, 1 a.a. - 269 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MSSYFVNSFSGRYPNGPDYQLLNYGSGSSLSGSYRDPAAMHTGSYGYNYNGMDLSVNRSSASSSHFGAVGESSRAFPAPAQEPRFRQAASSCSLSSPESLPCTNGDSHGAKPSASSPSDQATSASSSANFTEIDEASASSEPEEAASQLSSPSLARAQPEPMATSTAAPEGQTPQIFPWMRKLHISHDMTGPDGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKDNKLKSMSLATAGSAFQP
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
55.8
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — HOXB5
Entrez GeneID
3215GeneBank Accession#
NM_002147.3Protein Accession#
NP_002138.1Gene Name
HOXB5
Gene Alias
HHO.C10, HOX2, HOX2A, HU-1, Hox2.1
Gene Description
homeobox B5
Omim ID
142960Gene Ontology
HyperlinkGene Summary
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue. [provided by RefSeq
Other Designations
homeo box 2A|homeo box B5
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Interactomes
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Publication Reference
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HOXB5 binds to multi-species conserved sequence (MCS+9.7) of RET gene and regulates RET expression.
Zhu JJ, Kam MK, Garcia-Barcelo MM, Tam PK, Lui VC.
The International Journal of Biochemistry & Cell Biology 2014 Jun; 51:142.
Application:EMSA, Human, SK-N-SH cells.
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HOXB5 binds to multi-species conserved sequence (MCS+9.7) of RET gene and regulates RET expression.
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