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Last updated: 2017/12/10

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HMGCR 293T Cell Transient Overexpression Lysate(Denatured)

  • Catalog # : H00003156-T01
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  • Specification
  • Transfected Cell Line:
  • 293T
  • Plasmid:
  • pCMV-HMGCR full-length
  • Host:
  • Human
  • Theoretical MW (kDa):
  • 91.96
  • Quality Control Testing:
  • Transient overexpression cell lysate was tested with Anti-HMGCR antibody (H00003156-B01) by Western Blots.
    SDS-PAGE Gel
    QC Testing of H00003156-T01
    HMGCR transfected lysate.
    Western Blot
    QC Testing of H00003156-T01
    Lane 1: HMGCR transfected lysate ( 91.96 KDa)
    Lane 2: Non-transfected lysate.
  • Storage Buffer:
  • 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot
  • Application Image
  • Western Blot
  • Gene Information
  • Entrez GeneID:
  • 3156
  • Gene Name:
  • HMGCR
  • Gene Alias:
  • -
  • Gene Description:
  • 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
  • Gene Summary:
  • HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • 3-hydroxy-3-methylglutaryl CoA reductase (NADPH),hydroxymethylglutaryl-CoA reductase
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